UTTechMedCHOIRResearch & DevelopmentORAHS International Seminar Series

ORAHS International Seminar Series

Welcome to the ORAHS International Seminar Series!

Our next seminar on OR applied to Health Services is scheduled for September 24th.

The ORAHS International Seminar Series aims to provide state-of-the-art research talks for scholars worldwide who are active in the nexus of OR/OM and healthcare applications. We believe these seminars will prepare and support graduate students and researchers who are active in the field with the newest research conducted worldwide. Moreover, they provide opportunities for academic members to get acquainted and find possible future collaborations.

How to join?

The seminars are planned monthly, every last Tuesday of the month, via Zoom in the late afternoon (Europe), morning (US), or evening (Asia/Pacific).

Register now!

You can register soon for the upcoming seminar on September 24th 2024.

Upcoming seminars

September 24th, 16:00-17:00 CEST - Prof. Dimitris Bertsimas (Massachusetts Institute of Technology, USA) - The R.O.A.D. to precision medicine

Title The R.O.A.D. to precision medicine

Abstract We propose a prognostic stratum matching framework that uses optimization in its core that addresses the deficiencies of Randomized trial data subgroup analysis and transforms Observational Data to be used as if they were randomized, thus paving the road or precision medicine. Our approach counters the effects of unobserved confounding in observational data by correcting the estimated probabilities of the outcome under a treatment through a novel two-step process. We applied our framework to observational data of patients with gastrointestinal stromal tumors (GIST) and validated our approach in an external cohort using the sensitivity and specificity metrics. We show that these recommendations outperformed those of experts in GIST. We further applied the same framework to randomized clinical trial (RCT) data of patients with extremity sarcomas. Remarkably, despite the initial trial results suggesting that all patients should receive treatment, our framework, after addressing imbalances in patient distribution due to the trial’s small sample size, identified a subset of patients with unique characteristics who may not require treatment. Again, we successfully validated our recommendations in an external cohort. Joint work with Dr. Antonis Margonis and Angelos Koulouras.

Bio Dimitris Bertsimas is the Boeing Professor of Operations Research and the Associate Dean of Business Analytics at the Sloan School of Management at the Massachusetts Institute of Technology. He is a member of the US National Academy of Engineering, an INFORMS fellow, recipient of the John von Neumann Theory Prize, the Frederick W. Lanchester Prize, the Erlang Prize, finalist of the Franz Edelman Prize four times, and the INFORMS President's Award, among many other research and teaching awards, supervisor of 91 completed and 26 current doctoral theses, co-author of seven graduate level textbooks, 300+ publications, editor of the INFORMS Journal on Optimization and co-founder of ten analytics companies and two non-profit foundations.

 Registration You can register soon for the upcoming seminar on September 24th 2024.

Seminar archive

Recordings of our previous seminar talks are available below.

Organizing committee

The ORAHS international seminar series is organized by Amin Asadi, Aleida Braaksma, Derya Demirtas, Daniela Guericke, Gréanne Leeftink, Janusz Meylahn, Sebastian Rachuba, and Anne Zander of the CHOIR research center of the University of Twente (The Netherlands). For questions and inquiries feel free to reach out to us via email.

The ORAHS international seminar series is supported by its advisory board, consisting of Richard Boucherie (University of Twente, The Netherlands), and Erwin Hans (University of Twente, the Netherlands), and the ORAHS board.